Moxie is an uncommon yet distinctive female given name of unknown origin and uncertain meaning, first used in the United States during the early 20th century. Its etymology remains a mystery, with theories suggesting possible links to traditional Chinese medicine or shortened forms of popular names like Mozelle. The most recognized usage of 'moxie' as an adjective means 'displaying boldness or courage', but its intended meaning when first used as a name is unclear. Despite these uncertainties, Moxie has gained popularity in recent years, with 142 baby girls receiving the name in the United States in 2020. Its appeal likely lies in its unique sound and distinctive spelling, allowing for personal associations to shape its significance.